The active ingredient of the drug – mebicar is similar in chemical structure to natural metabolites organism – it consists of two molecules of methylated urea fragments comprising the bicyclic structure. The easily soluble in water and in many organic solvents. Mebicar chemically inert and does not react with acids, alkalis, oxidizing agents and reducing agents, various drugs and food components.
Mebicar effect on the activity of structures within the limbic-reticular complex, in particular, on emotiogenic hypothalamus area, and it has an effect on all 4 major neurotransmitter systems – GABA, cholinergic, serotonergic and adrenergic, helping them balance and integration, but not renders peripheral adrenonegativnogo action. It eliminates or reduces anxiety, anxiety, fear, internal emotional pressure and irritability. The calming effect is not accompanied by muscle relaxation and impaired motor coordination. It does not reduce the mental and motor activity, so mebicar can be used during the work day or school. It does not create an elevated mood, feelings of euphoria. Hypnotic effect does not possess, but enhances the effect of hypnotic drugs and improves during sleep with his violations. Mebicar eases or relieves nicotine withdrawal symptoms.
Also it has a calming effect nootropic effect. In clinical studies it has shown that mebicar improves consistency, coherence, and speed thinking, improves attention and mental abilities, are not stimulating the symptoms of productive psychopathological disorders – delirium, abnormal emotional activity.
Mebicar good (77-80%) absorbed from the gastrointestinal tract by up to 40% of the dose is bound by red blood cells. Rest does not bind to plasma proteins and is in a free form in plasma, so the active ingredient is distributed throughout the body smoothly and freely overcomes cell membranes. The maximum concentration of active ingredient in the blood is reached after 0.5 hours after administration and a high level is maintained for 3-4 hours, then gradually decreases. 55-70% of the dose excreted in the urine and the rest – with the feces as unchanged during the day.
Mebicar not metabolized and does not accumulate in the body.
Neuroses and neurosis-like states, occurring with symptoms of irritability, emotional instability, anxiety and fear. The drug is prescribed as to improve the tolerability of antipsychotics and tranquilizers in order to eliminate them caused somatovegetativnyh and neurological side effects. In clinic of internal medicine indicated for Adaptol cardialgia different genesis, not associated with coronary heart disease. The drug is used in combination therapy as a means of reducing the craving for tobacco smoking.
Individual hypersensitivity to the active substance or excipients of the drug.
Use of the drug during pregnancy and lactation.
The active ingredient of the drug penetrates well into all tissues and body fluids. There is a sufficient number of clinical observations on the use of the drug during pregnancy and lactation, so the drug is not recommended.
Dosing and Administration
Inside of meals of 500 mg 2-3 times a day. The maximum single dose is 3 grams daily – 10 g Duration of treatment – from several days to 2-3 months.
In the treatment as a means of reducing tobacco craving for smoking at 600-900 mg 3 times a day for 5-6 weeks.
If time is not a regular dose has been taken, the treatment is continued previously assigned dose. If necessary, consult with your doctor.
Adaptol usually well tolerated. After high doses, possible allergic reaction and dyspeptic disorders. In this case, you should stop taking the drug. Can reduce blood pressure and body temperature, which are normalized independently.
If during treatment with observed side effects not mentioned in the instructions for use, it is necessary to inform the treating physician.
The product has low toxicity. If you suspect overdose call a doctor to carry out conventional methods of detoxification, including gastric lavage.
Interaction with other drugs
Adaptol can be combined with antipsychotics, tranquilizers (benzodiazepines), hypnotics, antidepressants and psychostimulants.
An addictive, addiction and withdrawal symptoms are not set to Adaptol.