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AFOBAZOL (Afobazole) 10mg 300 tablets

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AFOBAZOL 10mg 300 tablets

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The active ingredient of Afobazol is the selective anxiolytic, which do not belong to the class of receptor agonists.

Revealed the following pharmacological properties of the drug:

Action of Afobazol is not accompanied witgipnosedativny effect.
No effect on memory and attention to negative (in contrast to similar medicines).
It has antianxiety (anxiolytic) and stimulating effect.
It reduces the level of psychological discomfort that is caused by the alarming conditions: concern, fear, foreboding, irritability and others.
It helps to eliminate muscular, cardiovascular, respiratory and sensory symptoms in patients with somatic disorders.
Significantly reduces the manifestation of autonomic disorders: excessive sweating, dry mouth, slight dizziness and others.
Focuses, improves memory.

7 in stock

SKU: AF10-300 Category:

Product Description

pharmachologic effect
The drug has anxiolytic (antianxiety) action.

It is a selective anxiolytic, not classified as benzodiazepine receptor agonists. Hinders development membranozavisimyh changes the gamma-aminobutyric acid receptor.

Anxiolytic effect occurs with an active current component and is not accompanied by a hypnotic and sedative effects (sedation expression is detected in a drug in doses, which are 40-50 times higher than the ED50 for the anxiolytic effect). There are no drug muscle relaxant properties, negative impact on attention and memory performance. Receiving the drug does not produce drug dependence and withdrawal forms.

Implementation of the action of the drug takes place mainly in the form of a combination of antianxiety (anxiolytic) and a minor activating (stimulating) effects. Reducing or eliminating anxiety (a bad feeling, anxiety, irritability, fear), strength (tearfulness, anxiety, fear, insomnia) are observed after Afobazol. Consequently, there is a decrease of vegetative (dry mouth, sweating, dizziness), somatic (sensory, muscular, cardiovascular, gastrointestinal, respiratory symptoms), cognitive (impaired memory, difficulty concentrating) violations fixed at 5-7 day drug therapy. Achieving maximum effect observed by the end of 4 weeks of therapy and maintained for 1-2 weeks in posleterapevticheskom period. The drug is recommended for use in patients with predominantly asthenic personality traits as emotional instability, uncertainty, anxiety and suspiciousness of increased vulnerability, susceptibility to stress and emotional reactions.

The drug is non-toxic (LD50 in rats is 1.1 g at ED50 0,001 g).

The average value of Cmax, ingestion of drugs (0,13 ± 0,073) g / ml; T1 / 2 – 0.82 hours; the average residence time in the body of the drug (MRT) -. (1,6 ± 0,86) h actively distributed in a well-vascularized organs.
Application Afobazol
Adults with various situations:
– Neurasthenia;
– Generalized anxiety disorder;
– Adjustment disorder.

In the combined therapy can be assigned Afobazol patients with various medical conditions:
– Irritable bowel syndrome;
– bronchial asthma;
– Systemic lupus erythematosus;
– cardiac ischemia;
– Arrhythmias;
– hypertonic disease.

And:
– Oncological, dermatological and other diseases;
– In the treatment of sleep disorders, which are associated with anxiety, premenstrual syndrome, neuro dystonia, alcohol withdrawal syndrome;
– To facilitate the patient’s condition during withdrawal when quitting smoking.
Side effects Afobazol
Allergic reactions.
Contraindications
Hypersensitivity to the components included in the composition of the drug. Pregnancy.
The period of breastfeeding. Children under 18 years Afobazol contraindicated.
Dosing Afobazol
Tablets taken orally after meals.

A single dose is 10 mg, the daily dosage of 30 mg, which is needed during the day divided into three doses. The duration of treatment is 2-4 weeks. If necessary, doctor recommendations and the daily dosage may be increased to 60 mg, and the duration of treatment rate increased to 3 months.
special instructions
In the case of drug overdose is possible to develop a soothing, atarakticheskogo (sedative) effect and development of the state without drowsiness tangible manifestations of muscle relaxation (in the case of a large overdose and toxicity). In this situation, as the emergency room subcutaneously injected 20% solution of caffeine sodium benzoate. Dosage – 1 ml 2-3 times.

Interaction with other drugs

The drug has no effect on the hypnotic effect of thiopental and narcotic effect of ethanol. There carbamazepine potentiates the anticonvulsant effect. In diazepam causes increased anxiolytic action.

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