Nootropic drug. According to the mechanism of action is a neuromodulator. It acts on most neurotransmitter systems of the brain. Has expressed antiamnesic action activates the integrative activity of the brain contributes to memory consolidation, improves concentration and mental performance, facilitates the learning process, accelerates the transfer of information between the hemispheres of the brain, increases resistance to brain tissue hypoxia and toxic effects, possesses anticonvulsant action and anxiolytic activity , regulates the processes of the central nervous system activation and inhibition, improves mood.
Phenotropil has a positive effect on the metabolism and cerebral blood flow, stimulates the redox processes, improves the body’s energy potential due to glucose utilization, improves regional blood flow in ischemic areas of the brain. Increases of noradrenaline, dopamine and serotonin in the brain.
It has no effect on the level of content of GABA, is not associated with GABAA- and GABAV receptors, has no significant effect on spontaneous bioelectrical activity of the brain.
it has no effect on the respiratory and cardiovascular systems. It has weakly expressed diuretic effect.
Phenotropil has moderate activating effect with respect to motor responses, increases physical performance, has a strong antagonism against cataleptic action of neuroleptics, reduces the severity of hypnotic action of ethanol and hexenal.
Moderate psychoactivating effect of the drug is combined with anxiolytic activity. Fenotropil improves mood, has an analgesic effect by raising the pain threshold.
Phenotropil has adaptogenic effect, increasing the body’s resistance to stress under conditions of increased mental and physical exertion, with fatigue, hypokinesia and immobilization at low temperatures.
Against the background of phenotropil marked improvement in vision (increased sharpness, brightness and field of view).
Phenotropil improves blood flow to the lower extremities.
Phenotropil stimulate antibody production in response to antigen indicating its immunostimulatory properties, but at the same time does not cause the development of immediate hypersensitivity reactions and does not modify the allergic inflammatory reaction of the skin caused by the introduction of the foreign protein.
In exchange application phenotropil not develop drug dependence and tolerance. In case of cancellation of the drug were observed the development of the syndrome.
Action phenotropil seen after a single dose, which is important when using the drug in extreme conditions.
Absorption and distribution
After intake of rapidly absorbed from the gastrointestinal tract, distributed in various organs and tissues, easily penetrates through the BBB. The absolute bioavailability of the drug when administered is 100%. Cmax is achieved in the blood after 1 hour.
Metabolism and excretion
Phenylpiracetam is not metabolized in the body and is excreted unchanged. About 40% is excreted in the urine, 60% – in the bile and then. T1 / 2 is 3-5 hours.
CNS: insomnia (while taking the drug after 15 hours).
Some patients in the first 3 days of receipt – psychomotor agitation, flushing of the skin, a feeling of warmth, increased blood pressure.