Therapeutic effect of Ladasten for patients with asthenia and anxiety-asthenic disorders manifested from the first day of its application in the form of a distinct reduction asthenic symptoms, indicators of emotional stress, somatovegetativnyh manifestations; medication helps to restore the activity and increase endurance.
Ladasten mechanism of action is associated with increased release of dopamine from presynaptic terminals, blockade of its re-uptake and biosynthesis enhancement caused gene expression of tyrosine hydroxylase, as well as its modulatory effect on the GABA-benzodiazepine-hlorionoformny receptor complex, eliminating decrease benzodiazepine reception, growing under stress . Ladasten enhances GABA-ergic mediation, reducing the expression of the gene controlling the synthesis of GABA-transporter carrying the reuptake of the neurotransmitter.
Ladasten, indications for use
asthenic conditions of various origins, including in somatic diseases and after infectious diseases;
Children up to age 18 years.
Dosing and Administration
Ladasten Inside, regardless of meals.
When asthenic conditions of various origins, including in somatic diseases and after infectious diseases and neurasthenia: the optimal single dose – 50-100 mg; DSA – 100-200 mg, distributed into 2 doses throughout the day. The drug should not be used after 16 hours of the day. The duration of a course of the drug is 2-4 weeks.
Pregnancy and breast-feeding
Do not use this Ladasten the drug during pregnancy and lactation (breastfeeding).
May include the activation and manifestation of excessive sleep disorders that do not require discontinuation of therapy (in this case it is advisable to reduce the dose). With increased individual sensitivity to the drug may develop allergic reactions.
Ladasten at simultaneous application reduces the hypnotic effect of thiopental sodium. While the use of benzodiazepines Lad does not weaken their anxiolytic effect.