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MEXIDOL (Emoxypine) 125mg 50 tablets


MEXIDOL 125mg 50 tablets

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Mexidol belongs to the pharmacological group “means acting on the nervous system.”

The product is characterized by:

membrane stabilizing;
anxiolytic properties.

In addition, it has a strong stress-protective effect (i.e., increases the body’s resistance to stress), improves memory, has the ability to prevent or stop attacks seizures, and also reduces the concentration of individual lipid fractions (including low density lipoproteins) in various tissues and body fluids.

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Product Description

Antioxidant drug.

It has anti-hypoxic, membrane-protective, nootropic, anticonvulsant, and anxiolytic effects, increases the body’s resistance to stress. The drug increases the body’s resistance to the effects of the main damaging factors to kislorodzavisimym pathological conditions (shock, hypoxia and ischemia, cerebrovascular accident, alcohol intoxication and antipsychotics / neuroleptics /).

Mexidol improves brain metabolism and blood flow to the brain, improves microcirculation and blood rheology, reduces platelet aggregation. It stabilizes the membrane structure of blood cells (erythrocytes and platelets) for hemolysis. It has hypolipidemic effect, reduces total cholesterol and LDL.

Reduces enzymatic toxemia and endogenous intoxication in acute pancreatitis.

The mechanism of action of the drug Mexidol due to its anti-hypoxic, antioxidant and membrane action. The drug inhibits lipid peroxidation, increases the activity of superoxide dismutase, increases the ratio of “lipid-protein”, reduces the viscosity of the membrane increases its fluidity.

Mexidol modulates the activity of membrane enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase) receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, it helps to preserve the structural and functional organization of biological membranes, transport of neurotransmitters and improve synaptic transmission. Mexidol increases the content of dopamine in the brain. It is a compensatory increase in the activity of aerobic glycolysis and decreased inhibition of oxidative processes in the Krebs cycle under hypoxic conditions, with an increase in ATP content, creatine and activation energosinteziruyuschih functions of mitochondria, stabilizing cell membranes.

Meksidol normalises metabolic processes in the ischemic myocardium reduces the zone of necrosis and regeneration of electrical activity and improves myocardial contractility and coronary blood flow increases in the zone of ischemia, reperfusion syndrome reduces effects in acute coronary insufficiency. Increases nitropreparatov antianginal activity. Mexidol contributes to the preservation of retinal ganglion cells and the optic nerve fibers in progressive neuropathy, caused by chronic ischemia and hypoxia. It improves the function of the retina and optic nerve activity, increasing visual acuity.



Mexidol when administered at doses of 400-500 mg Cmax in plasma is 3.5-4.0 mg / ml is reached within 0.45-0.5 hours.


After the / m of drug detected in the blood plasma for 4 hours. The average retention time of the drug in the body is 0.7-1.3 hours.


Excreted in the urine mainly in the form of glyukuronokonyugirovannoy and in small quantities – unchanged.
Mexidol, indications for use


acute cerebrovascular accident;
atherosclerotic disorders of brain function;
neurosis and neurotic disorders with anxiety manifestation;
relief of abstinence syndrome in alcoholism with the presence in the clinical picture of neurosis and vegetative-vascular disorders, and acute intoxication antipsychotics;
in treatment of acute purulent inflammation of the abdominal cavity (acute destructive pancreatitis, peritonitis).


effects of stroke, including after a transient ischemic attack, in phase subcompensation as prevention courses;
mild traumatic brain injury, the effects of traumatic brain injury;
encephalopathies of various origins (dyscirculatory, dysmetabolic, post-traumatic, mixed);
vegetative dystonia syndrome;
mild cognitive disorders of atherosclerotic;
anxiety disorders in neurotic and neurosis-like states;
Coronary heart disease (in the complex therapy);
relief of abstinence syndrome in alcoholism with a predominance of neurosis and vegetative-vascular disorders, postabstinentnom disorder;
state after acute intoxication antipsychotics;
asthenic conditions;
prevention of systemic diseases under the influence of extreme factors and loads;
exposure to extreme (stress) factors.


Increased individual sensitivity to the drug;
acute renal failure;
acute liver failure.

Due to insufficient knowledge of the drug – the children’s age, pregnancy, breastfeeding.
Dosing and Administration


Intramuscularly or intravenously (bolus or infusion).

When administered intravenously as a solvent used for water injection. Chip meksidol administered for 5-7 min, drip – a rate of 60 drops per minute. Doses picked individually.

Started treatment with a dose of 0.05-0.1 g 1-3 times a day, gradually increasing the dose to produce a therapeutic effect. The duration of treatment and the selection of individual dose depends on the severity of the patient’s condition and the effectiveness of treatment. The maximum daily dose should not exceed 0.8 g

For the treatment of atherosclerotic dementia in elderly patients prescribed mexidol / m at a dose of 0.1-0.3 g / day.

In acute intoxication neuroleptic drug is administered intravenously at a dose of 0,5-0,3 g / day.

In the complex treatment of acute purulent inflammation of the abdominal cavity (acute destructive pancreatitis, peritonitis) mexidol administered in a single dose of 200 mg 3 times a day. In severe disease the drug is diluted in 200 ml of physiological 0.9% sodium chloride solution and impose a speed of 40-60 drops per minute. When a minor illness mexidol introduced into / m. The course of treatment – 3-10 days.


Inside, in the 125-250 mg 3 times a day; the maximum daily dose – 800 mg (see Table 6.).

Duration of treatment – 2-6 weeks; for the relief of alcohol withdrawal – 5-7 days. Treatment stopped gradually, reducing the dose for 2-3 days.

The initial dose – 125-250 mg (1-2 tablets.) 1-2 times a day with a gradual increase until the therapeutic effect; the maximum daily dose – 800 mg (see Table 6.).

Duration of therapy in patients with coronary artery disease – at least 1,5-2 months. Repeated courses (on doctor’s advice), it is desirable to carry out in the spring and autumn periods.
Pregnancy and breast-feeding

Mexidol not recommended during pregnancy and lactation (breastfeeding) due to insufficient knowledge of the drug.
Side effects

From the digestive system: rarely – nausea, dry mouth.
Other: rarely – allergic reactions.
special instructions

Mexidol can be combined with all drugs used for the treatment of systemic diseases.

Use in Pediatrics

Mexidol not prescribed to children due to insufficient knowledge of the drug.

Effects on ability to drive vehicles and management mechanisms

During the period of treatment must be careful when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.

In some cases, especially in predisposed patients with bronchial asthma with hypersensitivity to sulfites may develop severe hypersensitivity reactions.
Drug interactions

In a joint application Mexidol enhances the action of benzodiazepines, antidepressants, anxiolytics, antiparkinsonian and anticonvulsants.

Mexidol reduces the toxic effects of ethanol.


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