The neuroprotective effect of Noopept is to increase the stability of brain tissue to damaging influences (trauma, hypoxia, electroconvulsive or toxic effects) and the weakening of the degree of damage to brain neurons. Noopept reduces focus on model thrombotic stroke and prevents neuronal death in the tissue culture of cerebral cortex and cerebellum, subjected to the action of neurotoxic glutamate concentrations, free-radical oxygen.
Noopept has an antioxidant effect, blocking the voltage-dependent calcium channels of neurons, weakening the neurotoxic effects of excess calcium. It improves blood rheology, possessing antiplatelet, fibrinolytic, anticoagulant properties.
Nootropic action of the drug associated with the formation tsikloprolilglitsina similar in structure to endogenous cyclic dipeptide possessing antiamnestic activity and the presence holinopozitivnogo action.
Noopept® transcallosal increases the amplitude of the response, facilitating associative links between the hemispheres of the brain at the level of cortical structures.
It helps restore memory and other cognitive functions, disturbed as a result of the damaging effects – brain trauma, local and global ischemia, prenatal damage (alcohol, hypoxia).
The therapeutic effect of the drug in patients with organic CNS diseases manifested with 5-7 days of treatment. Initially implemented anxiolytic and stimulating light effects, manifested in the reduction or disappearance of anxiety, irritability, affective lability, sleep disorders. After 14-20 days of therapy revealed a positive effect of the drug on cognitive function, attention and memory options.
Noopept® has vegetonormalizuyuschim action, helps to reduce headaches, orthostatic disorders, tachycardia.
When you remove the drug is observed withdrawal.
Do not have a damaging effect on the internal organs, does not lead to a change in the cellular composition of the blood and biochemical parameters of blood and urine; has no immunotoxic, teratogenic, does not exhibit mutagenic properties. It does not cause drug dependence.
Absorbed from the gastrointestinal tract. In an unmodified form it is absorbed into the systemic circulation. Cmax is achieved at a mean of 15 minutes. Bioavailability – 99.7%.
It penetrates through the BBB. Determined in high concentrations in the brain than in blood.
Metabolism and excretion
The drug is partially retained in unchanged form, partially metabolized with the formation of phenylacetic acid, and fenilatsetilprolina tsikloprolilglitsina.
T1 / 2 -. 0.38 hours Not accumulates in the body.
Indications for use of the drug
Violations of memory, attention and other cognitive functions, and emotionally labile disorder (including elderly patients) when:
– Effects of traumatic brain injury;
– Commotion syndrome;
– Cerebrovascular insufficiency (encephalopathy different genesis);
– Asthenic disorders;
– Other conditions with symptoms of decline of intellectual efficiency.
Noopept administered orally, after meals.
The drug is administered in an initial dose of 20 mg – 10 mg in 2 divided doses (morning and afternoon). In case of insufficient efficacy and good tolerability of the drug dose was increased to 30 mg – 10 mg in 3 divided doses during the day.
Do not take the medication within 18 hours.
The duration of the course of treatment is 1.5-3 months. Repeated treatment may optionally be performed 1 month later.
Perhaps: allergic reactions. In patients with hypertension, mostly severe, rise in blood pressure may occur in patients receiving the drug.
Contraindications to the use of the drug
– Lactation (breastfeeding);
– Child and adolescence to 18 years;
– Hypersensitivity to the drug;
– Lactase deficiency, lactose intolerance, malabsorption syndrome glucose / galactose;
– The expressed disturbances of liver function;
– The expressed disturbances of function of kidneys.
Use of the drug during pregnancy and breastfeeding
The drug is contraindicated during pregnancy and lactation (breastfeeding).
Not established teratogenic effects of the drug.
Application for violations of liver function
Do not use this praparata when expressed violations of liver function.
Application for violations of renal function
Do not use this praparata with marked renal dysfunction.